{"id":149,"date":"2018-08-16T22:57:11","date_gmt":"2018-08-16T13:57:11","guid":{"rendered":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/?p=149"},"modified":"2018-09-09T14:53:46","modified_gmt":"2018-09-09T05:53:46","slug":"pi3k","status":"publish","type":"post","link":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/recent\/pi3k\/","title":{"rendered":"PI3K\u7d4c\u8def\u3068\u306f"},"content":{"rendered":"

\u901a\u5e38\u3001\u7d30\u80de\u306e\u751f\u5b58\u30fb\u5897\u6b96\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u3053\u306e\u7d4c\u8def\u304c\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u816b\u760d\u306e\u5897\u6b96\u3001\u764c\u3092\u8a98\u767a\u3059\u308b\u4ed6\u7d4c\u8def\u3068\u306e\u9023\u643a\u3001\u6cbb\u7642\u62b5\u6297\u6027\u306e\u7372\u5f97\u306a\u3069\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u4e73\u764c\u3067\u306f\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3084HER2\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u306e\u7372\u5f97\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u7d4c\u8def\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u6cbb\u7642\u306e\u5927\u304d\u306a\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

2010 \u5e7412\u6708\u306b\u30b5\u30f3\u30a2\u30f3\u30c8\u30cb\u30aa\uff08USA\uff09\u3067\u958b\u50ac\u3055\u308c\u305f\u56fd\u969b\u4f1a\u8b70\u306e\u30c8\u30d4\u30c3\u30af\u30b9\u304b\u3089(\u4eca\u56de\u306e\u4f1a\u8b70\u3067\u6700\u3082\u6ce8\u76ee\u3092\u96c6\u3081\u305f\uff12\u3064\u306e\u30c6\u30fc\u30de\u304b\u3089\uff09<\/h3>\n

<1>dual blockade effective<\/h4>\n

HER2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8907\u6570\u306e\u65b9\u6cd5\u3067\u30d6\u30ed\u30c3\u30af\u3059\u308b\u65b9\u304c\u3001\u5358\u72ec\u306e\u30d6\u30ed\u30c3\u30af\u3088\u308a\u6709\u52b9\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u5177\u4f53\u7684\u306b\u306f\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\uff0b\u30e9\u30d1\u30c1\u30cb\u30d6\uff1e\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\u3000\u3042\u308b\u3044\u306f\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\uff0bpertuzumab\uff1e\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\u3068\u3044\u3046\u3053\u3068\u304c\u898b\u3048\u3066\u304d\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u9ad8\u984d\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u3067\u3059\u304c\u3001HER2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u5b8c\u5168\u30d6\u30ed\u30c3\u30af\u3068\u3044\u3046\u65b9\u6cd5\u3092\u5f53\u9762\u306f\u76ee\u6307\u3057\u3066\u7814\u7a76\u304c\u9032\u3080\u3068\u601d\u308f\u308c\u307e\u3059\u3002(GEPARQUINTO Trial, Neo-ALTTO Trial, NEOSPHERE Trial)<\/p>\n

<2>Azure trial : Negative Results<\/h4>\n

\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u306e\u30c8\u30e9\u30a4\u30a2\u30eb\uff08ABCSG-12\u30011800\u540d\u306e\u60a3\u8005\u3055\u3093\u304c\u53c2\u52a0\uff09\u306e\u7d50\u679c\u3067\u30be\u30e1\u30bf\u306e\u518d\u767a\u6291\u5236\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3001\u975e\u5e38\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3055\u3089\u306b\u5927\u898f\u6a21\u306a3360\u540d\u306e\u8a66\u9a13\u7d50\u679c\uff08Azure trial\uff09\u3067\u306f\u52b9\u679c\u304c\u5426\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u8a73\u7d30\u306a\u30c7\u30fc\u30bf\u89e3\u6790\u306f\u3053\u308c\u304b\u3089\u3067\u3059\u304c\u3001\u30be\u30e1\u30bf\u3092\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u4f7f\u3046\u3053\u3068\u306f\u307e\u3060\u307e\u3060\u7814\u7a76\u6bb5\u968e\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002
\n\uff1cThe Z0011 trial\u306b\u3064\u3044\u3066\uff1e<\/p>\n","protected":false},"excerpt":{"rendered":"

\u901a\u5e38\u3001\u7d30\u80de\u306e\u751f\u5b58\u30fb\u5897\u6b96\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u3053\u306e\u7d4c\u8def\u304c\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u816b\u760d\u306e\u5897\u6b96\u3001\u764c\u3092\u8a98\u767a\u3059\u308b\u4ed6\u7d4c\u8def\u3068\u306e\u9023\u643a\u3001\u6cbb\u7642\u62b5\u6297\u6027\u306e\u7372\u5f97\u306a\u3069\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u4e73\u764c\u3067\u306f\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3084HER2\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u306e\u7372\u5f97\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u7d4c\u8def\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u6cbb\u7642\u306e\u5927\u304d\u306a\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2010 \u5e7412\u6708\u306b\u30b5\u30f3\u30a2\u30f3\u30c8\u30cb\u30aa\uff08USA\uff09\u3067\u958b\u50ac\u3055\u308c\u305f\u56fd\u969b\u4f1a\u8b70\u306e\u30c8\u30d4\u30c3\u30af\u30b9\u304b\u3089(\u4eca\u56de\u306e\u4f1a\u8b70\u3067\u6700\u3082\u6ce8\u76ee\u3092\u96c6\u3081\u305f\uff12\u3064\u306e\u30c6\u30fc\u30de\u304b\u3089\uff09 <1>dual blockade effective HER2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8907\u6570\u306e\u65b9\u6cd5\u3067\u30d6\u30ed\u30c3\u30af\u3059\u308b\u65b9\u304c\u3001\u5358\u72ec\u306e\u30d6\u30ed\u30c3\u30af\u3088\u308a\u6709\u52b9\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u5177\u4f53\u7684\u306b\u306f\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\uff0b\u30e9\u30d1\u30c1\u30cb\u30d6\uff1e\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\u3000\u3042\u308b\u3044\u306f\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\uff0bpertuzumab\uff1e\u30c8\u30e9\u30b9\u30c4\u30c5\u30de\u30d6\u3068\u3044\u3046\u3053\u3068\u304c\u898b\u3048\u3066\u304d\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u9ad8\u984d\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u3067\u3059\u304c\u3001HER2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u5b8c\u5168\u30d6\u30ed\u30c3\u30af\u3068\u3044\u3046\u65b9\u6cd5\u3092\u5f53\u9762\u306f\u76ee\u6307\u3057\u3066\u7814\u7a76\u304c\u9032\u3080\u3068\u601d\u308f\u308c\u307e\u3059\u3002(GEPARQUINTO Trial, Neo-ALTTO Trial, NEOSPHERE Trial) <2>Azure trial : Negative Results \u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u306e\u30c8\u30e9\u30a4\u30a2\u30eb\uff08ABCSG-12\u30011800\u540d\u306e\u60a3\u8005\u3055\u3093\u304c\u53c2\u52a0\uff09\u306e\u7d50\u679c\u3067\u30be\u30e1\u30bf\u306e\u518d\u767a\u6291\u5236\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3001\u975e\u5e38\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u3055\u3089\u306b\u5927\u898f\u6a21\u306a3360\u540d\u306e\u8a66\u9a13\u7d50\u679c\uff08Azure trial\uff09\u3067\u306f\u52b9\u679c\u304c\u5426\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u8a73\u7d30\u306a\u30c7\u30fc\u30bf\u89e3\u6790\u306f\u3053\u308c\u304b\u3089\u3067\u3059\u304c\u3001\u30be\u30e1\u30bf\u3092\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u4f7f\u3046\u3053\u3068\u306f\u307e\u3060\u307e\u3060\u7814\u7a76\u6bb5\u968e\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002 \uff1cThe Z0011 trial\u306b\u3064\u3044\u3066\uff1e<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-149","post","type-post","status-publish","format-standard","hentry","category-recent"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/posts\/149"}],"collection":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/comments?post=149"}],"version-history":[{"count":1,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/posts\/149\/revisions"}],"predecessor-version":[{"id":150,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/posts\/149\/revisions\/150"}],"wp:attachment":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/media?parent=149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/categories?post=149"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/exclusive\/wp-json\/wp\/v2\/tags?post=149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}