{"id":559,"date":"2024-10-25T17:14:38","date_gmt":"2024-10-25T08:14:38","guid":{"rendered":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/?p=559"},"modified":"2024-10-25T17:36:40","modified_gmt":"2024-10-25T08:36:40","slug":"hboc","status":"publish","type":"post","link":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/%e4%b9%b3%e3%81%8c%e3%82%93%e3%81%ae%e6%89%8b%e8%a1%93\/hboc\/","title":{"rendered":"\u907a\u4f1d\u6027\u4e73\u764c\u5375\u764c\u5de3\u75c7\u5019\u7fa4\u306b\u3064\u3044\u3066"},"content":{"rendered":"

\u907a\u4f1d\u6027\u4e73\u764c\u5375\u5de3\u764c\u75c7\u5019\u7fa4\uff08Hereditary Breast and Ovarian Cancer syndrome: HBOC\uff09\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308a\u4e73\u764c\u3084\u5375\u5de3\u764c\u304c\u767a\u75c7\u3057\u3084\u3059\u304f\u306a\u308b\u75c7\u5019\u7fa4\u3067\u3001BRCA1\u304a\u3088\u3073BRCA2\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3059\u3002\u4ee5\u4e0b\u306fHBOC\u306b\u3064\u3044\u3066\u306e\u307e\u3068\u3081\u3067\u3059\u3002<\/p>\n

1. \u907a\u4f1d\u6027\u4e73\u764c\u5375\u5de3\u764c\u75c7\u5019\u7fa4\u3068\u306f<\/h3>\n

HBOC\u306f\u3001\u7279\u306bBRCA1\u3068BRCA2\u3068\u547c\u3070\u308c\u308b\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u751f\u3059\u308b\u907a\u4f1d\u7684\u75be\u60a3\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306b\u5206\u88c2\u3057DNA\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306b\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u306a\u304f\u306a\u308a\u3001\u764c\u304c\u767a\u751f\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002HBOC\u306f\u4e73\u764c\u3068\u5375\u5de3\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8457\u3057\u304f\u9ad8\u3081\u308b\u307b\u304b\u3001\u81b5\u764c\u3084\u524d\u7acb\u817a\u764c\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3082\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

2. HBOC\u306e\u539f\u56e0\u3068\u907a\u4f1d\u7684\u80cc\u666f<\/h3>\n

BRCA1\u304a\u3088\u3073BRCA2\u306f\u3001DNA\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u7570\u5e38\u304c\u3042\u308b\u3068DNA\u306e\u30a8\u30e9\u30fc\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001\u304c\u3093\u7d30\u80de\u306e\u5f62\u6210\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002BRCA\u907a\u4f1d\u5b50\u5909\u7570\u306e\u907a\u4f1d\u5f62\u614b\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\u3067\u3042\u308a\u3001\u7247\u65b9\u306e\u89aa\u304c\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u5b50\u4f9b\u304c50\uff05\u306e\u78ba\u7387\u3067\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002BRCA1\u3068BRCA2\u306b\u95a2\u3059\u308b\u5909\u7570\u306f\u3001\u4e16\u754c\u7684\u306b\u7570\u306a\u308b\u96c6\u56e3\u9593\u3067\u7570\u306a\u308b\u983b\u5ea6\u3067\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u7279\u5b9a\u306e\u6c11\u65cf\u3084\u5730\u57df\u306b\u304a\u3044\u3066\u306f\u9ad8\u983b\u5ea6\u3067\u307f\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

3. BRCA1\u304a\u3088\u3073BRCA2\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3068\u5f79\u5272<\/h3>\n

BRCA1\u3068BRCA2\u306f\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3067\u3001\u7d30\u80de\u5468\u671f\u306e\u9032\u884c\u3092\u8abf\u7bc0\u3057DNA\u4fee\u5fa9\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002BRCA1\u306fDNA\u4fee\u5fa9\u3001\u8ee2\u5199\u8abf\u7bc0\u3001\u304a\u3088\u3073\u7d30\u80de\u5468\u671f\u306e\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3001BRCA2\u306f\u7279\u306bDNA\u306e\u4e8c\u672c\u9396\u5207\u65ad\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6a5f\u80fd\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u3044\u3068\u3001\u7d30\u80de\u306fDNA\u640d\u50b7\u3092\u62b1\u3048\u305f\u307e\u307e\u5897\u6b96\u3057\u3001\u764c\u306e\u30ea\u30b9\u30af\u304c\u5897\u5927\u3057\u307e\u3059\u3002<\/p>\n

4. HBOC\u306b\u95a2\u9023\u3059\u308b\u764c\u306e\u30ea\u30b9\u30af<\/h3>\n

BRCA1\u304a\u3088\u3073BRCA2\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u5973\u6027\u306e\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u306f\u7d0412\uff05\u3068\u3055\u308c\u307e\u3059\u304c\u3001BRCA1\u5909\u7570\u4fdd\u6709\u8005\u3067\u306f\u7d0470\uff05\u3001BRCA2\u5909\u7570\u4fdd\u6709\u8005\u3067\u306f\u7d0445\u301c60\uff05\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u5375\u5de3\u764c\u306b\u95a2\u3057\u3066\u3082\u3001\u4e00\u822c\u306e\u30ea\u30b9\u30af\u304c1\u301c2\uff05\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001BRCA1\u5909\u7570\u4fdd\u6709\u8005\u306f40\uff05\u3001BRCA2\u5909\u7570\u4fdd\u6709\u8005\u306f15\u301c20\uff05\u3068\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7537\u6027\u3082BRCA\u5909\u7570\u306b\u3088\u308a\u524d\u7acb\u817a\u764c\u3084\u4e73\u764c\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

5. HBOC\u306e\u8a3a\u65ad\u3068\u907a\u4f1d\u5b50\u691c\u67fb<\/h3>\n

HBOC\u306e\u8a3a\u65ad\u306b\u306f\u3001\u5bb6\u65cf\u6b74\u306e\u78ba\u8a8d\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u91cd\u8981\u3067\u3059\u3002\u7279\u306b\u82e5\u5e74\u3067\u306e\u4e73\u764c\u3084\u5375\u5de3\u764c\u306e\u767a\u75c7\u3001\u5bb6\u65cf\u5185\u3067\u306e\u8907\u6570\u306e\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u75c7\u4f8b\u304c\u307f\u3089\u308c\u308b\u5834\u5408\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u3001\u8840\u6db2\u3084\u553e\u6db2\u304b\u3089DNA\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u3001BRCA1\u304a\u3088\u3073BRCA2\u306e\u5909\u7570\u306e\u6709\u7121\u3092\u8abf\u3079\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u533b\u5e2b\u306e\u6307\u793a\u306e\u3082\u3068\u3067\u884c\u308f\u308c\u3001\u4fdd\u967a\u9069\u7528\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u305f\u3046\u3048\u3067\u691c\u67fb\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

6. \u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u8005\u3078\u306e\u7ba1\u7406\u3068\u6cbb\u7642<\/h3>\n

HBOC\u3067BRCA\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001\u767a\u764c\u30ea\u30b9\u30af\u7ba1\u7406\u3068\u3057\u3066\u4ee5\u4e0b\u306e\u65b9\u6cd5\u304c\u8003\u616e\u3055\u308c\u307e\u3059\u3002<\/p>\n

a. \u5b9a\u671f\u7684\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/h4>\n

BRCA\u5909\u7570\u4fdd\u6709\u8005\u306f\u4e73\u764c\u3084\u5375\u5de3\u764c\u306e\u65e9\u671f\u767a\u898b\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u5b9a\u671f\u7684\u306a\u4e73\u623f\u691c\u67fb\u3084\u753b\u50cf\u8a3a\u65ad\uff08MRI\u3084\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u30fc\uff09\u3092\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306e\u3042\u308b\u5973\u6027\u306b\u5bfe\u3057\u3066\u306f\u3001\u7d4c\u81a3\u8d85\u97f3\u6ce2\u691c\u67fb\u3084\u816b\u760d\u30de\u30fc\u30ab\u30fc\uff08CA-125\uff09\u3092\u7528\u3044\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u65bd\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

b. \u4e88\u9632\u7684\u624b\u8853<\/h4>\n

\u4e73\u623f\u3084\u5375\u5de3\u306e\u4e88\u9632\u7684\u5207\u9664\uff08\u30ea\u30b9\u30af\u4f4e\u6e1b\u624b\u8853\uff09\u3082\u9078\u629e\u80a2\u306e\u4e00\u3064\u3067\u3059\u3002\u4e73\u623f\u5207\u9664\u306f\u3001\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u309290\uff05\u4ee5\u4e0a\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5375\u5de3\u6458\u51fa\u624b\u8853\uff08\u5375\u7ba1\u5375\u5de3\u6458\u9664\u8853\uff09\u306f\u3001\u5375\u5de3\u764c\u304a\u3088\u3073\u5375\u7ba1\u764c\u306e\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u4f4e\u6e1b\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308a\u3001\u9589\u7d4c\u524d\u306b\u884c\u3046\u5834\u5408\u306b\u306f\u4e73\u764c\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u6e1b\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

c. \u5316\u5b66\u4e88\u9632<\/h4>\n

\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u3084\u30e9\u30ed\u30ad\u30b7\u30d5\u30a7\u30f3\u3068\u3044\u3063\u305f\u6297\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u85ac\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4e73\u764c\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3055\u305b\u308b\u8a66\u307f\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5316\u5b66\u4e88\u9632\u85ac\u306e\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u305f\u3081\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u901a\u3058\u305f\u30ea\u30b9\u30af\u8a55\u4fa1\u3068\u76f8\u8ac7\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n

7. HBOC\u306b\u304a\u3051\u308b\u5fc3\u7406\u7684\u652f\u63f4\u3068\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/h3>\n

HBOC\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\u3001\u60a3\u8005\u3084\u305d\u306e\u5bb6\u65cf\u306b\u306f\u5fc3\u7406\u7684\u306a\u30b5\u30dd\u30fc\u30c8\u304c\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e0d\u5b89\u3084\u3001\u4e88\u9632\u7684\u624b\u8853\u306b\u5bfe\u3059\u308b\u5fc3\u7406\u7684\u8ca0\u62c5\u304c\u5927\u304d\u3044\u305f\u3081\u3001\u5fc3\u7406\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5bb6\u65cf\u3078\u306e\u907a\u4f1d\u60c5\u5831\u306e\u5171\u6709\u306b\u3064\u3044\u3066\u3082\u914d\u616e\u304c\u5fc5\u8981\u3067\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u304c\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3053\u3068\u3067\u3001\u5bb6\u65cf\u5168\u4f53\u306e\u30ea\u30b9\u30af\u7ba1\u7406\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

8. \u6700\u65b0\u306e\u6cbb\u7642\u3068\u7814\u7a76\u52d5\u5411\uff08\u30ea\u30f3\u30af\u3042\u308a\uff09<\/a><\/h3>\n

\u8fd1\u5e74\u3067\u306f\u3001BRCA\u5909\u7570\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u7279\u306bPARP\u963b\u5bb3\u85ac\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002PARP\u963b\u5bb3\u85ac\u306f\u3001BRCA\u5909\u7570\u7d30\u80de\u306eDNA\u4fee\u5fa9\u6a5f\u80fd\u306e\u6b20\u640d\u3092\u5229\u7528\u3057\u3066\u764c\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u653b\u6483\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3001\u4e73\u764c\u3084\u5375\u5de3\u764c\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u826f\u597d\u306a\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u514d\u75ab\u7642\u6cd5\u3084\u4ed6\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3082\u691c\u8a0e\u3055\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306eHBOC\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u304c\u5e83\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

9. HBOC\u3068\u793e\u4f1a\u7684\u5f71\u97ff<\/h3>\n

HBOC\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u3084\u4e88\u9632\u7684\u6cbb\u7642\u306e\u666e\u53ca\u306b\u4f34\u3044\u3001\u793e\u4f1a\u7684\u306a\u8ab2\u984c\u3082\u6d6e\u304d\u5f6b\u308a\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u4fdd\u967a\u5236\u5ea6\u306e\u5145\u5b9f\u3084\u907a\u4f1d\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u304c\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002\u307e\u305f\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6b63\u3057\u3044\u77e5\u8b58\u306e\u666e\u53ca\u3068\u504f\u898b\u306e\u89e3\u6d88\u304c\u6c42\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u6559\u80b2\u3084\u5553\u767a\u6d3b\u52d5\u304c\u63a8\u9032\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

10. \u307e\u3068\u3081<\/h3>\n

\u907a\u4f1d\u6027\u4e73\u764c\u5375\u5de3\u764c\u75c7\u5019\u7fa4\uff08HBOC\uff09\u306f\u3001BRCA1\u304a\u3088\u3073BRCA2\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u4e73\u764c\u3084\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u75be\u60a3\u3067\u3059\u3002\u8a3a\u65ad\u306b\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u7528\u3044\u3089\u308c\u3001\u5b9a\u671f\u7684\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u4e88\u9632\u7684\u624b\u8853\u3001\u5316\u5b66\u4e88\u9632\u3068\u3044\u3063\u305f\u30ea\u30b9\u30af\u4f4e\u6e1b\u624b\u6bb5\u304c\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3084\u5fc3\u7406\u7684\u652f\u63f4\u3082\u4e0d\u53ef\u6b20\u3067\u3001\u60a3\u8005\u3084\u5bb6\u65cf\u306e\u5fc3\u8eab\u306e\u30b1\u30a2\u304c\u91cd\u8981\u3067\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u306b\u3088\u308a\u3001PARP\u963b\u5bb3\u85ac\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u9032\u5c55\u3057\u3064\u3064\u3042\u308a\u3001HBOC\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u306e\u9078\u629e\u80a2\u304c\u5e83\u304c\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u907a\u4f1d\u6027\u4e73\u764c\u5375\u5de3\u764c\u75c7\u5019\u7fa4\uff08Hereditary Breast and Ovarian Cancer syndrome: HBOC\uff09\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308a\u4e73\u764c\u3084\u5375\u5de3\u764c\u304c\u767a\u75c7\u3057\u3084\u3059\u304f\u306a\u308b\u75c7\u5019\u7fa4\u3067\u3001BRCA1\u304a\u3088\u3073BRCA2\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3059\u3002\u4ee5\u4e0b\u306fHBOC\u306b\u3064\u3044\u3066\u306e\u307e\u3068\u3081\u3067\u3059\u3002 1. \u907a\u4f1d\u6027\u4e73\u764c\u5375\u5de3\u764c\u75c7\u5019\u7fa4\u3068\u306f HBOC\u306f\u3001\u7279\u306bBRCA1\u3068BRCA2\u3068\u547c\u3070\u308c\u308b\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u751f\u3059\u308b\u907a\u4f1d\u7684\u75be\u60a3\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306b\u5206\u88c2\u3057DNA\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306b\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u306a\u304f\u306a\u308a\u3001\u764c\u304c\u767a\u751f\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002HBOC\u306f\u4e73\u764c\u3068\u5375\u5de3\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8457\u3057\u304f\u9ad8\u3081\u308b\u307b\u304b\u3001\u81b5\u764c\u3084\u524d\u7acb\u817a\u764c\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3082\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 2. HBOC\u306e\u539f\u56e0\u3068\u907a\u4f1d\u7684\u80cc\u666f BRCA1\u304a\u3088\u3073BRCA2\u306f\u3001DNA\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u7570\u5e38\u304c\u3042\u308b\u3068DNA\u306e\u30a8\u30e9\u30fc\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001\u304c\u3093\u7d30\u80de\u306e\u5f62\u6210\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002BRCA\u907a\u4f1d\u5b50\u5909\u7570\u306e\u907a\u4f1d\u5f62\u614b\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\u3067\u3042\u308a\u3001\u7247\u65b9\u306e\u89aa\u304c\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u5b50\u4f9b\u304c50\uff05\u306e\u78ba\u7387\u3067\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002BRCA1\u3068BRCA2\u306b\u95a2\u3059\u308b\u5909\u7570\u306f\u3001\u4e16\u754c\u7684\u306b\u7570\u306a\u308b\u96c6\u56e3\u9593\u3067\u7570\u306a\u308b\u983b\u5ea6\u3067\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u7279\u5b9a\u306e\u6c11\u65cf\u3084\u5730\u57df\u306b\u304a\u3044\u3066\u306f\u9ad8\u983b\u5ea6\u3067\u307f\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002 3. BRCA1\u304a\u3088\u3073BRCA2\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3068\u5f79\u5272 BRCA1\u3068BRCA2\u306f\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3067\u3001\u7d30\u80de\u5468\u671f\u306e\u9032\u884c\u3092\u8abf\u7bc0\u3057DNA\u4fee\u5fa9\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002BRCA1\u306fDNA\u4fee\u5fa9\u3001\u8ee2\u5199\u8abf\u7bc0\u3001\u304a\u3088\u3073\u7d30\u80de\u5468\u671f\u306e\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3001BRCA2\u306f\u7279\u306bDNA\u306e\u4e8c\u672c\u9396\u5207\u65ad\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6a5f\u80fd\u304c\u6b63\u5e38\u306b\u50cd\u304b\u306a\u3044\u3068\u3001\u7d30\u80de\u306fDNA\u640d\u50b7\u3092\u62b1\u3048\u305f\u307e\u307e\u5897\u6b96\u3057\u3001\u764c\u306e\u30ea\u30b9\u30af\u304c\u5897\u5927\u3057\u307e\u3059\u3002 4. HBOC\u306b\u95a2\u9023\u3059\u308b\u764c\u306e\u30ea\u30b9\u30af BRCA1\u304a\u3088\u3073BRCA2\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u5973\u6027\u306e\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u306f\u7d0412\uff05\u3068\u3055\u308c\u307e\u3059\u304c\u3001BRCA1\u5909\u7570\u4fdd\u6709\u8005\u3067\u306f\u7d0470\uff05\u3001BRCA2\u5909\u7570\u4fdd\u6709\u8005\u3067\u306f\u7d0445\u301c60\uff05\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u5375\u5de3\u764c\u306b\u95a2\u3057\u3066\u3082\u3001\u4e00\u822c\u306e\u30ea\u30b9\u30af\u304c1\u301c2\uff05\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001BRCA1\u5909\u7570\u4fdd\u6709\u8005\u306f40\uff05\u3001BRCA2\u5909\u7570\u4fdd\u6709\u8005\u306f15\u301c20\uff05\u3068\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7537\u6027\u3082BRCA\u5909\u7570\u306b\u3088\u308a\u30fb\u30fb\u30fb<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,13,12,7],"tags":[],"class_list":["post-559","post","type-post","status-publish","format-standard","hentry","category-15","category-13","category-hboc","category-7"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/559"}],"collection":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/comments?post=559"}],"version-history":[{"count":6,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/559\/revisions"}],"predecessor-version":[{"id":567,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/559\/revisions\/567"}],"wp:attachment":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/media?parent=559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/categories?post=559"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/tags?post=559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}