{"id":568,"date":"2024-10-26T00:15:13","date_gmt":"2024-10-25T15:15:13","guid":{"rendered":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/?p=568"},"modified":"2024-10-26T00:16:24","modified_gmt":"2024-10-25T15:16:24","slug":"tnbc12","status":"publish","type":"post","link":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/approach\/tnbc12\/","title":{"rendered":"\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u306b\u304a\u3051\u308b\u6700\u65b0\u7814\u7a76\u6210\u679c"},"content":{"rendered":"

\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\uff08TNBC\uff09\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u3001\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53\uff08PR\uff09\u3001\u30d2\u30c8\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f532\uff08HER2\uff09\u306e\u3044\u305a\u308c\u306b\u3082\u967d\u6027\u53cd\u5fdc\u3092\u793a\u3055\u306a\u3044\u4e73\u304c\u3093\u3092\u6307\u3057\u3001\u4e73\u304c\u3093\u306e\u4e2d\u3067\u3082\u4e88\u5f8c\u304c\u60aa\u304f\u3001\u6a19\u6e96\u7684\u306a\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3084\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306e\u6069\u6075\u3092\u53d7\u3051\u306b\u304f\u3044\u30bf\u30a4\u30d7\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001TNBC\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306f\u6025\u52d9\u3067\u3042\u308a\u3001\u8fd1\u5e74\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u3092\u3044\u304f\u3064\u304b\u306e\u4e3b\u8981\u306a\u5206\u91ce\u306b\u5206\u3051\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n

1. \u514d\u75ab\u7642\u6cd5\u306e\u9032\u5c55<\/h3>\n

TNBC\u306f\u9ad8\u3044\u60aa\u6027\u5ea6\u3092\u6301\u3064\u53cd\u9762\u3001\u816b\u760d\u6d78\u6f64\u30ea\u30f3\u30d1\u7403\uff08TILs\uff09\u304c\u591a\u304f\u898b\u3089\u308c\u308b\u305f\u3081\u3001\u514d\u75ab\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08ICI\uff09\u3068\u3057\u3066\u306f\u3001\u6297PD-1\u6297\u4f53\u3084\u6297PD-L1\u6297\u4f53\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u30a2\u30c6\u30be\u30ea\u30ba\u30de\u30d6\u3084\u30da\u30f3\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u304c\u3001\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\u3067TNBC\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306bPD-L1\u967d\u6027\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u5f93\u6765\u306e\u6cbb\u7642\u3088\u308a\u3082\u751f\u5b58\u7387\u3092\u5ef6\u9577\u3055\u305b\u308b\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

2. PARP\u963b\u5bb3\u5264\u306e\u5f79\u5272<\/h3>\n

TNBC\u306e\u60a3\u8005\u306e\u4e00\u90e8\u306f\u3001BRCA1\u307e\u305f\u306fBRCA2\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306fPARP\u963b\u5bb3\u5264\u304c\u6709\u52b9\u3067\u3059\u3002PARP\u963b\u5bb3\u5264\u306f\u3001DNA\u4fee\u5fa9\u6a5f\u80fd\u3092\u963b\u5bb3\u3057\u3001\u304c\u3093\u7d30\u80de\u306e\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u85ac\u5264\u3068\u3057\u3066\u30aa\u30e9\u30d1\u30ea\u30d6\u3084\u30bf\u30e9\u30be\u30d1\u30ea\u30d6\u304c\u3042\u308a\u3001BRCA\u5909\u7570\u3092\u6301\u3064TNBC\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001BRCA\u5909\u7570\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u306f\u65b0\u305f\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

3. \u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\uff08ADC\uff09\u306e\u958b\u767a<\/h3>\n

ADC\u306f\u6297\u4f53\u3068\u5316\u5b66\u7642\u6cd5\u85ac\u3092\u7d50\u5408\u3055\u305b\u305f\u85ac\u5264\u3067\u3001\u304c\u3093\u7d30\u80de\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u5185\u306b\u85ac\u5264\u3092\u76f4\u63a5\u9001\u308a\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6700\u8fd1\u3067\u306f\u3001\u30b5\u30b7\u30c4\u30ba\u30de\u30d6\u30fb\u30b4\u30d3\u30c6\u30ab\u30f3\u304cTNBC\u306b\u5bfe\u3057\u3066\u627f\u8a8d\u3055\u308c\u3001\u5316\u5b66\u7642\u6cd5\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u60a3\u8005\u306b\u3082\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u85ac\u5264\u306f\u3001\u30c8\u30ed\u30dd2\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3001\u304c\u3093\u7d30\u80de\u5185\u306b\u76f4\u63a5\u85ac\u7269\u3092\u9001\u308b\u3053\u3068\u3067\u3001\u6b63\u5e38\u306a\u7d30\u80de\u3078\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3064\u3064\u3001\u816b\u760d\u7d30\u80de\u306e\u6bba\u50b7\u52b9\u679c\u3092\u9ad8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n

4. \u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u306b\u3088\u308b\u500b\u5225\u5316\u533b\u7642\u306e\u63a8\u9032<\/h3>\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u304c\u3093\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u304c\u3088\u308a\u8a73\u7d30\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002TNBC\u306f\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u591a\u69d8\u6027\u304c\u9ad8\u3044\u305f\u3081\u3001\u60a3\u8005\u3054\u3068\u306b\u7570\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4f8b\u3048\u3070PI3K\u3001AKT\u3001mTOR\u7d4c\u8def\u306a\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u7570\u5e38\u304c\u3042\u308b\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u305d\u308c\u305e\u308c\u306b\u9069\u3057\u305f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u6cbb\u7642\u52b9\u679c\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

5. \u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306e\u6a19\u7684\u5316<\/h3>\n

TNBC\u306f\u5468\u56f2\u306e\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u304c\u816b\u760d\u306e\u9032\u884c\u3084\u6cbb\u7642\u62b5\u6297\u6027\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001TME\u3092\u6a19\u7684\u3068\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u816b\u760d\u3092\u53d6\u308a\u5dfb\u304f\u514d\u75ab\u7d30\u80de\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u3001\u8840\u7ba1\u306a\u3069\u306b\u50cd\u304d\u304b\u3051\u3001\u304c\u3093\u7d30\u80de\u306e\u6210\u9577\u3092\u6291\u5236\u3059\u308b\u65b9\u6cd5\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002TME\u306e\u8abf\u7bc0\u306b\u3088\u308a\u3001\u514d\u75ab\u7642\u6cd5\u3084\u4ed6\u306e\u6cbb\u7642\u6cd5\u306e\u52b9\u679c\u304c\u5411\u4e0a\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

6. \u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u63a2\u7d22<\/h3>\n

TNBC\u306b\u304a\u3051\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u63a2\u7d22\u3082\u9032\u5c55\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u3084HER2\u306e\u3088\u3046\u306a\u6a19\u6e96\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u5b58\u5728\u3057\u306a\u3044\u305f\u3081\u3001\u6cbb\u7642\u52b9\u679c\u3084\u4e88\u5f8c\u3092\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u6307\u6a19\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001CTCs\uff08\u5faa\u74b0\u816b\u760d\u7d30\u80de\uff09\u3084cfDNA\uff08\u8840\u6f3f\u4e2d\u5faa\u74b0\u816b\u760dDNA\uff09\u3068\u3044\u3063\u305f\u3001\u8840\u6db2\u4e2d\u306e\u5206\u5b50\u3092\u7528\u3044\u305f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u975e\u4fb5\u8972\u7684\u306b\u60a3\u8005\u306e\u72b6\u614b\u3092\u8ffd\u8de1\u3057\u3001\u6cbb\u7642\u52b9\u679c\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

7. \u5316\u5b66\u7642\u6cd5\u306e\u6700\u9069\u5316\u3068\u65b0\u898f\u85ac\u5264<\/h3>\n

TNBC\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u5316\u5b66\u7642\u6cd5\u304c\u4e3b\u8981\u306a\u4f4d\u7f6e\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u304c\u3001\u65b0\u898f\u85ac\u5264\u306e\u5c0e\u5165\u3084\u65e2\u5b58\u306e\u85ac\u5264\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306e\u5411\u4e0a\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u3092\u542b\u3080\u30ec\u30b8\u30e1\u30f3\u304cTNBC\u60a3\u8005\u306b\u5bfe\u3057\u3066\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30ab\u30da\u30b7\u30bf\u30d3\u30f3\u306a\u3069\u306e\u7d4c\u53e3\u85ac\u3092\u7528\u3044\u305f\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u304c\u3001\u518d\u767a\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u5bfe\u3057\u3066\u6709\u671b\u3067\u3042\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

8. \u30e1\u30bf\u30dc\u30ea\u30ba\u30e0\u7d4c\u8def\u306e\u6a19\u7684\u5316<\/h3>\n

TNBC\u306f\u4ed6\u306e\u4e73\u304c\u3093\u30bf\u30a4\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u4ee3\u8b1d\u306e\u7570\u5e38\u304c\u591a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u4e73\u9178\u306e\u751f\u6210\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u816b\u760d\u306e\u6210\u9577\u3092\u963b\u5bb3\u3059\u308b\u65b9\u6cd5\u3084\u3001\u8102\u8cea\u4ee3\u8b1d\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u3092\u906e\u65ad\u3059\u308b\u3053\u3068\u3067\u3001\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

9. \u5c06\u6765\u7684\u306a\u5c55\u671b\u3068\u8ab2\u984c<\/h3>\n

\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u306f\u3001\u514d\u75ab\u7642\u6cd5\u3001PARP\u963b\u5bb3\u5264\u3001ADC\u3001\u4ee3\u8b1d\u7d4c\u8def\u306e\u6a19\u7684\u5316\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u6025\u901f\u306b\u9032\u5c55\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u6cbb\u7642\u6cd5\u306b\u306f\u8ab2\u984c\u3082\u5b58\u5728\u3057\u3001\u4f8b\u3048\u3070\u3001\u6cbb\u7642\u53cd\u5fdc\u3092\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306e\u78ba\u7acb\u3055\u308c\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u6b20\u5982\u3084\u3001\u6cbb\u7642\u8cbb\u7528\u306e\u9ad8\u3055\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001TNBC\u306f\u7570\u7a2e\u6027\u304c\u9ad8\u304f\u3001\u60a3\u8005\u3054\u3068\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3084\u816b\u760d\u306e\u7279\u5fb4\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u4eca\u5f8c\u306f\u500b\u5225\u5316\u533b\u7642\u306e\u3055\u3089\u306a\u308b\u9032\u5c55\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n

\u307e\u3068\u3081<\/h3>\n

\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\u306f\u4e88\u5f8c\u304c\u60aa\u304f\u6cbb\u7642\u304c\u96e3\u3057\u3044\u4e73\u304c\u3093\u306e\u4e00\u3064\u3067\u3059\u304c\u3001\u6700\u65b0\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u514d\u75ab\u7642\u6cd5\u3084PARP\u963b\u5bb3\u5264\u3001\u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\u306a\u3069\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u60a3\u8005\u3054\u3068\u306e\u816b\u760d\u306e\u7279\u5fb4\u306b\u57fa\u3065\u3044\u305f\u500b\u5225\u5316\u533b\u7642\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u4eca\u5f8c\u306e\u6cbb\u7642\u306e\u9375\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u52a0\u3048\u3066\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u3084\u4ee3\u8b1d\u7d4c\u8def\u3078\u306e\u50cd\u304d\u304b\u3051\u3082\u91cd\u8981\u306a\u7814\u7a76\u5206\u91ce\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f15\u304d\u7d9a\u304d\u3001TNBC\u306e\u751f\u7269\u5b66\u7684\u7279\u6027\u306b\u5bfe\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3068\u81e8\u5e8a\u5fdc\u7528\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30c8\u30ea\u30d7\u30eb\u30cd\u30ac\u30c6\u30a3\u30d6\u4e73\u304c\u3093\uff08TNBC\uff09\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u3001\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53\uff08PR\uff09\u3001\u30d2\u30c8\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f532\uff08HER2\uff09\u306e\u3044\u305a\u308c\u306b\u3082\u967d\u6027\u53cd\u5fdc\u3092\u793a\u3055\u306a\u3044\u4e73\u304c\u3093\u3092\u6307\u3057\u3001\u4e73\u304c\u3093\u306e\u4e2d\u3067\u3082\u4e88\u5f8c\u304c\u60aa\u304f\u3001\u6a19\u6e96\u7684\u306a\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3084\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306e\u6069\u6075\u3092\u53d7\u3051\u306b\u304f\u3044\u30bf\u30a4\u30d7\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001TNBC\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306f\u6025\u52d9\u3067\u3042\u308a\u3001\u8fd1\u5e74\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u3092\u3044\u304f\u3064\u304b\u306e\u4e3b\u8981\u306a\u5206\u91ce\u306b\u5206\u3051\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002 1. \u514d\u75ab\u7642\u6cd5\u306e\u9032\u5c55 TNBC\u306f\u9ad8\u3044\u60aa\u6027\u5ea6\u3092\u6301\u3064\u53cd\u9762\u3001\u816b\u760d\u6d78\u6f64\u30ea\u30f3\u30d1\u7403\uff08TILs\uff09\u304c\u591a\u304f\u898b\u3089\u308c\u308b\u305f\u3081\u3001\u514d\u75ab\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08ICI\uff09\u3068\u3057\u3066\u306f\u3001\u6297PD-1\u6297\u4f53\u3084\u6297PD-L1\u6297\u4f53\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u30a2\u30c6\u30be\u30ea\u30ba\u30de\u30d6\u3084\u30da\u30f3\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u304c\u3001\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\u3067TNBC\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306bPD-L1\u967d\u6027\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u5f93\u6765\u306e\u6cbb\u7642\u3088\u308a\u3082\u751f\u5b58\u7387\u3092\u5ef6\u9577\u3055\u305b\u308b\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2. PARP\u963b\u5bb3\u5264\u306e\u5f79\u5272 TNBC\u306e\u60a3\u8005\u306e\u4e00\u90e8\u306f\u3001BRCA1\u307e\u305f\u306fBRCA2\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306fPARP\u963b\u5bb3\u5264\u304c\u6709\u52b9\u3067\u3059\u3002PARP\u963b\u5bb3\u5264\u306f\u3001DNA\u4fee\u5fa9\u6a5f\u80fd\u3092\u963b\u5bb3\u3057\u3001\u304c\u3093\u7d30\u80de\u306e\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u85ac\u5264\u3068\u3057\u3066\u30aa\u30e9\u30d1\u30ea\u30d6\u3084\u30bf\u30e9\u30be\u30d1\u30ea\u30d6\u304c\u3042\u308a\u3001BRCA\u5909\u7570\u3092\u6301\u3064TNBC\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001BRCA\u5909\u7570\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u306f\u65b0\u305f\u306a\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002 3. \u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\uff08ADC\uff09\u306e\u958b\u767a ADC\u306f\u6297\u4f53\u3068\u5316\u5b66\u7642\u6cd5\u85ac\u3092\u7d50\u5408\u3055\u305b\u305f\u85ac\u5264\u3067\u3001\u304c\u3093\u7d30\u80de\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u5185\u306b\u85ac\u5264\u3092\u76f4\u63a5\u9001\u308a\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6700\u8fd1\u3067\u306f\u3001\u30b5\u30b7\u30c4\u30ba\u30de\u30d6\u30fb\u30b4\u30d3\u30c6\u30ab\u30f3\u304cTNBC\u306b\u5bfe\u3057\u3066\u627f\u8a8d\u3055\u308c\u3001\u5316\u5b66\u7642\u6cd5\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u60a3\u8005\u306b\u3082\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u85ac\u5264\u306f\u3001\u30c8\u30ed\u30dd2\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3001\u304c\u3093\u7d30\u80de\u5185\u306b\u76f4\u63a5\u85ac\u7269\u3092\u9001\u308b\u3053\u3068\u3067\u3001\u6b63\u5e38\u306a\u7d30\u80de\u3078\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3064\u3064\u3001\u816b\u760d\u7d30\u80de\u306e\u6bba\u50b7\u52b9\u679c\u3092\u9ad8\u3081\u3066\u3044\u307e\u3059\u3002 4. \u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u306b\u3088\u308b\u500b\u5225\u5316\u533b\u7642\u306e\u63a8\u9032 \u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u304c\u3093\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u304c\u3088\u308a\u8a73\u7d30\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002TNBC\u306f\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u591a\u69d8\u30fb\u30fb\u30fb<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,12,2],"tags":[],"class_list":["post-568","post","type-post","status-publish","format-standard","hentry","category-15","category-hboc","category-approach"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/568"}],"collection":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/comments?post=568"}],"version-history":[{"count":1,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/568\/revisions"}],"predecessor-version":[{"id":569,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/568\/revisions\/569"}],"wp:attachment":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/media?parent=568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/categories?post=568"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/tags?post=568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}