{"id":649,"date":"2025-09-07T23:25:52","date_gmt":"2025-09-07T14:25:52","guid":{"rendered":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/?p=649"},"modified":"2025-09-07T23:26:14","modified_gmt":"2025-09-07T14:26:14","slug":"%e5%b0%8f%e3%81%95%e3%81%aaher2%e9%99%bd%e6%80%a7%e4%b9%b3%e7%99%8c%e3%81%ae%e4%ba%88%e5%be%8c%e3%81%a8%e8%96%ac%e7%89%a9%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/%e8%96%ac%e7%89%a9%e7%99%82%e6%b3%95\/%e5%b0%8f%e3%81%95%e3%81%aaher2%e9%99%bd%e6%80%a7%e4%b9%b3%e7%99%8c%e3%81%ae%e4%ba%88%e5%be%8c%e3%81%a8%e8%96%ac%e7%89%a9%e7%99%82%e6%b3%95\/","title":{"rendered":"\u5c0f\u3055\u306aHER2\u967d\u6027\u4e73\u764c\u306e\u4e88\u5f8c\u3068\u85ac\u7269\u7642\u6cd5"},"content":{"rendered":"<p><strong>\u5c0f\u3055\u306aHER2\u967d\u6027\u4e73\u764c\u306e\u300c\u4e88\u5f8c\u300d\u3068\u300c\u85ac\u7269\u7642\u6cd5\u300d<\/strong><\/p>\n<p><strong>1) <\/strong><strong>\u5bfe\u8c61\u3068\u80cc\u666f<\/strong><\/p>\n<p>\u3053\u3053\u3067\u3044\u3046\u300c\u5c0f\u3055\u306a\u300dHER2\u967d\u6027\u4e73\u764c\u306f\u3001\u4e00\u822c\u306b<strong>T1mi\uff08\u5fae\u5c0f\u6d78\u6f64<\/strong><strong>\u2264<\/strong><strong>1mm<\/strong><strong>\uff09\/T1a\uff08&gt;0.1\u2013<\/strong><strong>\u2264<\/strong><strong>0.5cm<\/strong><strong>\uff09\/T1b\uff08&gt;0.5\u2013<\/strong><strong>\u2264<\/strong><strong>1.0cm<\/strong><strong>\uff09\/T1c\uff08&gt;1.0\u2013<\/strong><strong>\u2264<\/strong><strong>2.0cm<\/strong><strong>\uff09\u304b\u3064N0<\/strong>\u3092\u6307\u3057\u307e\u3059\u3002\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff08HR\uff09\u967d\u6027\/\u9670\u6027\u3001\u7d44\u7e54\u5b66\u7684\u7570\u578b\u5ea6\u3001\u8108\u7ba1\u4fb5\u8972\uff08LVI\uff09\u306e\u6709\u7121\u306a\u3069\u306b\u3088\u308a\u518d\u767a\u30ea\u30b9\u30af\u306f\u63fa\u308c\u307e\u3059\u3002\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u6982\u306d\u3001<strong>T1a\/b\u306e\u591a\u304f\u3067\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u306f\u201c\u7e2e\u5c0f\uff08de-escalation\uff09\u201d\u3092\u57fa\u672c<\/strong>\u3068\u3057\u3001\u75c5\u614b\u306b\u5fdc\u3058\u3066\u6297HER2\u7642\u6cd5\u306e\u8981\u5426\u3092\u691c\u8a0e\u3059\u308b\u7acb\u5834\u3067\u3059\u3002<\/p>\n<p><strong>2) <\/strong><strong>\u4e88\u5f8c\u306e\u6982\u89b3<\/strong><\/p>\n<ul>\n<li><strong>T1miN0<\/strong>\uff1aNCCN\/ESMO\u3067\u306f<strong>\u5168\u8eab\u6cbb\u7642\uff08\u6297HER2\/\u5316\u5b66\u7642\u6cd5\uff09\u306f\u539f\u5247\u63a8\u5968\u305b\u305a<\/strong>\u3001HR\u967d\u6027\u306a\u3089\u5185\u5206\u6ccc\u7642\u6cd5\u3092\u8003\u616e\u3001\u3068\u3044\u3046\u6574\u7406\u304c\u4e00\u822c\u7684\u3067\u3059\uff08\u5c40\u6240\u6cbb\u7642\u304c\u57fa\u672c\uff09\u3002\u305f\u3060\u3057\u591a\u767a\u5fae\u5c0f\u6d78\u6f64\u3084HR\u9670\u6027\u306a\u3069\u306e\u4f8b\u5916\u306f\u500b\u5225\u691c\u8a0e\u3002<\/li>\n<li><strong>T1aN0<\/strong>\uff1a\u81ea\u7136\u7d4c\u904e\u306f\u6bd4\u8f03\u7684\u826f\u597d\u3067\u3001<strong>\u5316\u5b66\u7642\u6cd5\uff0b\u6297HER2\u306e\u7d76\u5bfe\u4e0a\u4e57\u305b\u52b9\u679c\u306f\u5c0f\u3055\u3044\/\u4e0d\u78ba\u5b9f<\/strong>\u3068\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067HR\u9670\u6027\u3084\u9ad8\u7570\u578b\u5ea6\u3001LVI\u967d\u6027\u3067\u306f\u76f8\u5bfe\u7684\u5229\u76ca\u304c\u5897\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/li>\n<li><strong>T1b\/cN0<\/strong>\uff1a\u518d\u767a\u30ea\u30b9\u30af\u306fT1a\u3088\u308a\u9ad8\u304f\u3001<strong>\u6297HER2\u7642\u6cd5\u4f75\u7528\u306e\u88dc\u52a9\u7642\u6cd5\u306b\u3088\u308b\u660e\u78ba\u306a\u30ea\u30b9\u30af\u4f4e\u4e0b<\/strong>\u304c\u591a\u6570\u306e\u81e8\u5e8a\u30fb\u5b9f\u81e8\u5e8a\u30c7\u30fc\u30bf\u3067\u652f\u6301\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u306fAPT\u8a66\u9a13\u3068\u305d\u306e\u8ffd\u8de1\u3001\u5fc5\u8981\u306b\u5fdc\u3058ATEMPT\u306e\u77e5\u898b\u3082\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><strong>3) <\/strong><strong>\u6a19\u6e96\u7684\u306a\u88dc\u52a9\u85ac\u7269\u7642\u6cd5\uff08\u8853\u5f8c\u3001pT1a\u2013cN0\u60f3\u5b9a\uff09<\/strong><\/p>\n<ol>\n<li><strong> TH<\/strong><strong>\u30ec\u30b8\u30e1\u30f3\uff08\u90311\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb\uff0b\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\uff09<\/strong><\/li>\n<\/ol>\n<p><strong>APT<\/strong><strong>\u8a66\u9a13<\/strong>\u306fT\u22643cm\u30fbN0\u306eHER2\u967d\u6027398\u4f8b\u8d85\u3092\u5bfe\u8c61\u306b\u3001<strong>\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb12\u9031\uff0b\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\u8a081\u5e74<\/strong>\u306e\u5358\u7fa4\u7b2cII\u76f8\u3002<strong>\u6700\u7d4210\u5e74\u89e3\u6790<\/strong>\u3067<strong>10\u5e74iDFS 91.3%<\/strong>\u3001<strong>RFI 96.3%<\/strong>\u3001<strong>OS 94.3%<\/strong>\u3001\u4e73\u764c\u7279\u7570\u7684\u751f\u5b5898.8%\u3068\u6975\u3081\u3066\u826f\u597d\u3067\u3057\u305f\u3002\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u306f\u8ab2\u984c\u3067\u3059\u304c\u3001**T1b\/c\u3084\u81e8\u5e8a\u7684\u306b\u201c\u4f4e\u301c\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u201d**\u306e\u591a\u304f\u3067\u73fe\u5b9f\u7684\u306a\u7b2c\u4e00\u9078\u629e\u3067\u3059\u3002<\/p>\n<ol>\n<li><strong> T-DM1<\/strong><strong>\u5358\u52641\u5e74\uff08ATEMPT\uff09<\/strong><\/li>\n<\/ol>\n<p><strong>ATEMPT<\/strong><strong>\u8a66\u9a13<\/strong>\uff08T-DM1 1\u5e74 vs TH\u30013:1\u7121\u4f5c\u70ba\u5316\uff095\u5e74\u8ffd\u8de1\u3067\u306f\u3001<strong>T-DM1\u7fa4\u306e5\u5e74iDFS 97.0%<\/strong>\u3001\u9060\u9694\u518d\u767a\u306f<strong>\u308f\u305a\u304b3\u4f8b<\/strong>\u3002\u7dcf\u5408\u7684\u306a\u201c\u81e8\u5e8a\u7684\u306b\u95a2\u9023\u3059\u308b\u6bd2\u6027\u201d\u306e\u983b\u5ea6\u306f\u6982\u306d<strong>T-DM1 46% vs TH 47%\u3067\u540c\u7a0b\u5ea6\u306a\u304c\u3089\u3001T-DM1\u306f\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u30fb\u8131\u6bdb\u304c\u5c11\u306a\u304f\u3001\u4e00\u65b9\u3067\u809d\u9175\u7d20\u4e0a\u6607\u30fb\u8840\u5c0f\u677f\u6e1b\u5c11\u3001\u6cbb\u7642\u4e2d\u6b62\u304c\u3084\u3084\u591a\u3044<\/strong>\u3068\u3044\u3046\u201c\u6bd2\u6027\u306e\u8cea\u201d\u306e\u9055\u3044\u304c\u7279\u5fb4\u3067\u3059\u3002<strong>TH\u304c\u96e3\u3057\u3044\u795e\u7d4c\u969c\u5bb3\u30ea\u30b9\u30af\u75c7\u4f8b<\/strong>\u3084\u3001\u4ed5\u4e8b\u30fbQOL\u9762\u3067\u201c\u8131\u6bdb\/\u3057\u3073\u308c\u201d\u3092\u7279\u306b\u56de\u907f\u3057\u305f\u3044\u60a3\u8005\u3067\u9078\u629e\u80a2\u306b\u306a\u308a\u307e\u3059\uff08\u4fdd\u967a\u9069\u7528\u30fb\u8cbb\u7528\u306f\u5730\u57df\u5dee\u306b\u7559\u610f\uff09\u3002<\/p>\n<ol>\n<li><strong>\u3044\u3064\u201c\u5f37\u5316\u201d\u3092\u8003\u3048\u308b\u304b<\/strong><\/li>\n<\/ol>\n<p><strong>T1c<\/strong><strong>\u3067\u3082N0\u306a\u3089\u901a\u5e38\u306fTH\uff08\u307e\u305f\u306fT-DM1\uff09\u3067\u5341\u5206<\/strong>\u3068\u3055\u308c\u307e\u3059\u304c\u3001<strong>HR\u9670\u6027\u30fb\u9ad8\u7570\u578b\u5ea6\u30fb\u5e83\u7bc4LVI\u306a\u3069\u306e\u201c\u751f\u7269\u5b66\u7684\u9ad8\u30ea\u30b9\u30af\u201d\u3067\u3042\u308c\u3070\u3001TCbH\uff08\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\uff0b\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\uff0bH\uff09\u7b49\u3092\u691c\u8a0e\u3059\u308b\u65bd\u8a2d\u3082\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u88dc\u52a9PERTUZUMAB\u306fAPHINITY<\/strong>\u9577\u671f\u8ffd\u8de1\u3067<strong>\u4e3b\u306b\u30ea\u30f3\u30d1\u7bc0\u967d\u6027\u7fa4\u306b\u6069\u6075<\/strong>\u304c\u6b8b\u308b\u3053\u3068\u304c\u518d\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001<strong>N0\u4f8b\u3067\u306e routine \u8ffd\u52a0\u306f\u63a8\u5968\u3055\u308c\u307e\u305b\u3093<\/strong>\u3002<\/p>\n<p><strong>4) <\/strong><strong>\u4f8b\u5916\u30fb\u500b\u5225\u5316\uff1a\u5e74\u9f62\/\u4f75\u5b58\u75c7\u3068\u6cbb\u7642\u7e2e\u5c0f<\/strong><\/p>\n<p><strong>RESPECT<\/strong><strong>\u8a66\u9a13<\/strong>\uff08\u65e5\u672c\u300170\u201380\u6b73\uff09\u3067\u306f\u3001<strong>\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\u5358\u5264 vs \u5316\u5b66\u7642\u6cd5\uff0b\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6<\/strong>\u3092\u6bd4\u8f03\u3002<strong>3\u5e74DFS\uff1a89.5% vs 93.8%\u3067\u975e\u52a3\u6027\u306f\u8a3c\u660e\u3055\u308c\u305a<\/strong>\u3067\u3057\u305f\u304c\u3001<strong>\u6bd2\u6027\u306f\u660e\u3089\u304b\u306b\u8efd\u304f\u3001QOL\u306f\u826f\u597d<\/strong>\u3068\u3044\u3046\u7d50\u679c\u3002<strong>\u5f37\u3044\u865a\u5f31\u6027\u3084\u6709\u5bb3\u4e8b\u8c61\u61f8\u5ff5\u3067\u5316\u5b66\u7642\u6cd5\u304c\u56f0\u96e3<\/strong>\u306a\u9ad8\u9f62\u8005\u3067\u306f\u3001<strong>\u5341\u5206\u306a\u8aac\u660e\u3068\u5408\u610f\u306e\u3046\u3048\u5358\u5264H<\/strong>\u3092\u201c\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u9078\u629e\u80a2\u201d\u3068\u3057\u3066\u691c\u8a0e\u3057\u5f97\u307e\u3059\uff08\u6a19\u6e96\u3088\u308a\u306f\u59a5\u5354\u6848\uff09\u3002<\/p>\n<p><strong>5) <\/strong><strong>\u6295\u4e0e\u671f\u9593\u3068\u5fc3\u6bd2\u6027\u306e\u6271\u3044<\/strong><\/p>\n<ul>\n<li><strong>\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\u671f\u9593<\/strong>\uff1a\u56fd\u969b\u7684\u6a19\u6e96\u306f**\u201c1\u5e74\u201d<strong>\u3067\u3059\u304c\u3001PERSEPHONE\u3067\u306f<\/strong>\u201c6\u304b\u6708\u201d\u304c\u201c12\u304b\u6708\u201d\u306b\u5bfe\u3057\u975e\u52a3\u6027<strong>\u3092\u793a\u3057\u3001\u5fc3\u969c\u5bb3\u306a\u3069\u6709\u5bb3\u4e8b\u8c61\u3082\u5c11\u306a\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f4e\u30ea\u30b9\u30af\u4f8b\u3084\u5fc3\u6a5f\u80fd\u4f4e\u4e0b\u6642\u306e<\/strong>\u77ed\u7e2e\u691c\u8a0e**\u306b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308a\u307e\u3059\uff08\u305f\u3060\u3057\u56fd\/\u65bd\u8a2d\u3067\u904b\u7528\u5dee\u304c\u3042\u308b\u70b9\u306b\u7559\u610f\uff09\u3002<\/li>\n<li><strong>\u5fc3\u6a5f\u80fd\u7ba1\u7406<\/strong>\uff1aH\/T-DM1\u3044\u305a\u308c\u3082\u5fc3\u6bd2\u6027\u306f<strong>\u7a00\u3060\u304c\u30bc\u30ed\u3067\u306f\u306a\u3044<\/strong>\u305f\u3081\u3001<strong>\u958b\u59cb\u524d\u30fb\u6cbb\u7642\u4e2d\u306eLVEF\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong>\u304c\u63a8\u5968\u3002ATEMPT\u89e3\u6790\u3067\u306f**T-DM1\u306e\u91cd\u5ea6LVEF\u4f4e\u4e0b\u306f\u7d040.8%**\u3068\u4f4e\u983b\u5ea6\u3067\u3057\u305f\u3002<\/li>\n<\/ul>\n<p><strong>6) <\/strong><strong>\u5b9f\u8df5\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\uff08\u76ee\u5b89\uff09<\/strong><\/p>\n<ul>\n<li><strong>T1miN0<\/strong>\uff1a<strong>\u5168\u8eab\u6cbb\u7642\u4e0d\u8981<\/strong>\uff08HR\u967d\u6027\u306a\u3089\u5185\u5206\u6ccc\u7642\u6cd5\uff0b\u653e\u5c04\u7dda\u3092\u72b6\u6cc1\u306b\u5fdc\u3058\u691c\u8a0e\uff09\u3002<\/li>\n<li><strong>T1aN0<\/strong>\uff1a\n<ul>\n<li><strong>HR<\/strong><strong>\u967d\u6027\u30fb\u4f4e\u30b0\u30ec\u30fc\u30c9\u30fbLVI\u9670\u6027<\/strong>\u2192<strong>\u7d4c\u904e\u89b3\u5bdf\u00b1\u5185\u5206\u6ccc\u7642\u6cd5<\/strong>\u3082\u59a5\u5f53\u3002\u6297HER2\u5c0e\u5165\u306f<strong>\u75c7\u4f8b\u9078\u629e<\/strong>\u3002<\/li>\n<li><strong>HR<\/strong><strong>\u9670\u6027\uff0f\u9ad8\u30ea\u30b9\u30af\u6240\u898b<\/strong>\u2192**TH\uff0812\u9031\uff0bH\u8a081\u5e74\uff09**\u3092\u7a4d\u6975\u691c\u8a0e\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>T1bN0<\/strong>\uff1a<strong>TH\uff08\u6a19\u6e96\uff09<\/strong>\u3001<strong>\u4ee3\u66ff\u3068\u3057\u3066T-DM1 1\u5e74<\/strong>\u3092\u72b6\u6cc1\u3067\u9078\u629e\u3002HR\u967d\u6027\u306a\u3089<strong>\u5185\u5206\u6ccc\u7642\u6cd5\u8ffd\u52a0<\/strong>\u3002<\/li>\n<li><strong>T1cN0<\/strong>\uff1a\u591a\u304f\u306f<strong>TH<\/strong>\uff08\u307e\u305f\u306f<strong>T-DM1<\/strong>\uff09\u3002<strong>HR\u9670\u6027\u30fb\u9ad8\u30ea\u30b9\u30af<\/strong>\u3067\u306f<strong>TCbH\u7b49<\/strong>\u3092\u500b\u5225\u691c\u8a0e\u3002<strong>\u8853\u524d\u7642\u6cd5<\/strong>\u306f\u30b5\u30a4\u30ba\u63a8\u5b9a\u304c\u4e0d\u78ba\u304b\/\u591a\u767a\u306a\u3069\u306e\u3068\u304d\u306b\u9078\u629e\u80a2\u3002<\/li>\n<li><strong>\u9ad8\u9f62\u30fb\u30cf\u30a4\u30d5\u30ec\u30a4\u30eb<\/strong>\uff1a<strong>H\u5358\u5264<\/strong>\u3068\u3044\u3046\u201c\u7e2e\u5c0f\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u201d\u306f<strong>\u975e\u52a3\u6027\u306f\u672a\u9054<\/strong>\u3060\u304c<strong>\u81e8\u5e8a\u7684\u306a\u59a5\u5f53\u6027<\/strong>\u3042\u308a\u3002\u5408\u4f75\u75c7\u3084\u60a3\u8005\u4fa1\u5024\u89b3\u3068\u30d0\u30e9\u30f3\u30b9\u3002<\/li>\n<li><strong>PERTUZUMAB<\/strong><strong>\u8ffd\u52a0<\/strong>\uff1a<strong>N0\u3067\u306f\u539f\u5247\u4e0d\u8981<\/strong>\uff08APHINITY\u9577\u671f\u3067\u6069\u6075\u306f\u4e3b\u306bN+\uff09\u3002<\/li>\n<li><strong>H<\/strong><strong>\u671f\u9593\u77ed\u7e2e<\/strong>\uff1a<strong>6\u304b\u6708H<\/strong>\u306f<strong>\u975e\u52a3\u6027<\/strong>\u306e\u6839\u62e0\u3042\u308a\u3002\u5fc3\u6bd2\u6027\u3084\u793e\u4f1a\u7684\u8981\u56e0\u3067<strong>\u500b\u5225\u77ed\u7e2e<\/strong>\u3092\u691c\u8a0e\u3002<\/li>\n<\/ul>\n<p><strong>7) <\/strong><strong>\u65e5\u672c\u306e\u5b9f\u81e8\u5e8a\u30e1\u30e2<\/strong><\/p>\n<p>\u65e5\u672c\u4e73\u764c\u5b66\u4f1a\uff08JBCS\uff09\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u56fd\u969b\u6307\u91dd\u3068\u6982\u306d\u6574\u5408\u3057\u3001**\u5c0f\u816b\u760dHER2\u967d\u6027\u3067\u306f\u201cTH\u4e2d\u5fc3\u306e\u7e2e\u5c0f\u88dc\u52a9\u7642\u6cd5\u201d**\u3092\u57fa\u76e4\u306b\u500b\u5225\u5316\u3059\u308b\u6d41\u308c\u3067\u3059\uff08\u75c5\u7406\u8a3a\u65ad\u30fbHER2\u5224\u5b9a\u306fASCO\/CAP 2023\u6539\u8a02\u3092\u53cd\u6620\uff09\u3002\u500b\u3005\u306e\u9069\u5fdc\u30fb\u7528\u6cd5\u306f\u6700\u65b0\u7248\u306e\u9662\u5185\u30ec\u30b8\u30e1\u30f3\/\u8a3a\u7642\u79d1\u65b9\u91dd\u306b\u5f93\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u307e\u3068\u3081\uff08\u30dd\u30a4\u30f3\u30c8\uff09<\/strong><\/p>\n<ul>\n<li><strong>T1mi<\/strong>\u306f<strong>\u539f\u5247\u3001\u5168\u8eab\u6cbb\u7642\u4e0d\u8981<\/strong>\u3002<strong>T1a<\/strong>\u306f<strong>\u75c7\u4f8b\u9078\u629e<\/strong>\u3001<strong>T1b\/c<\/strong>\u306f**TH\uff08\u00b1\u5185\u5206\u6ccc\uff09**\u304c\u5b9f\u81e8\u5e8a\u306e\u67f1\u3002<\/li>\n<li><strong>APT<\/strong><strong>\u6700\u7d4210\u5e74<\/strong>\u306f<strong>\u9577\u671f\u6210\u7e3e\u304d\u308f\u3081\u3066\u826f\u597d<\/strong>\u3067\u201c\u7e2e\u5c0f\u88dc\u52a9\u7642\u6cd5\u201d\u306e\u6a19\u6e96\u3092\u78ba\u7acb\u3002<strong>ATEMPT<\/strong>\u306f<strong>T-DM1<\/strong>\u306e<strong>\u9ad8\u3044\u6709\u52b9\u6027\u3068\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u9055\u3044<\/strong>\u3092\u793a\u3057\u3001<strong>TH\u306e\u4ee3\u66ff<\/strong>\u306b\u306a\u308a\u5f97\u308b\u3002<\/li>\n<li><strong>PERTUZUMAB<\/strong>\u306f<strong>N0\u3067\u306f\u901a\u5e38\u4e0d\u8981<\/strong>\u3002<strong>H 6\u304b\u6708\u77ed\u7e2e<\/strong>\u306f<strong>\u975e\u52a3\u6027<\/strong>\u306e\u6839\u62e0\u3042\u308a\u3001\u5fc3\u6bd2\u6027\u3084\u5408\u4f75\u75c7\u3067\u6d3b\u7528\u3002<strong>\u9ad8\u9f62\/\u8106\u5f31\u4f8b<\/strong>\u3067\u306f<strong>H\u5358\u5264<\/strong>\u3068\u3044\u3046\u201c\u73fe\u5b9f\u7684\u306a\u9078\u629e\u80a2\u201d\u3082\u3001\u975e\u52a3\u6027\u672a\u9054\u3092\u8aac\u660e\u306e\u3046\u3048\u3067\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5c0f\u3055\u306aHER2\u967d\u6027\u4e73\u764c\u306e\u300c\u4e88\u5f8c\u300d\u3068\u300c\u85ac\u7269\u7642\u6cd5\u300d 1) \u5bfe\u8c61\u3068\u80cc\u666f 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T1b\/cN0\uff1a\u518d\u767a\u30ea\u30b9\u30af\u306fT1a\u3088\u308a\u9ad8\u304f\u3001\u6297HER2\u7642\u6cd5\u4f75\u7528\u306e\u88dc\u52a9\u7642\u6cd5\u306b\u3088\u308b\u660e\u78ba\u306a\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u591a\u6570\u306e\u81e8\u5e8a\u30fb\u5b9f\u81e8\u5e8a\u30c7\u30fc\u30bf\u3067\u652f\u6301\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u306fAPT\u8a66\u9a13\u3068\u305d\u306e\u8ffd\u8de1\u3001\u5fc5\u8981\u306b\u5fdc\u3058ATEMPT\u306e\u77e5\u898b\u3082\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u3002 3) \u6a19\u6e96\u7684\u306a\u88dc\u52a9\u85ac\u7269\u7642\u6cd5\uff08\u8853\u5f8c\u3001pT1a\u2013cN0\u60f3\u5b9a\uff09 TH\u30ec\u30b8\u30e1\u30f3\uff08\u90311\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb\uff0b\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\uff09 APT\u8a66\u9a13\u306fT\u22643cm\u30fbN0\u306eHER2\u967d\u6027398\u4f8b\u8d85\u3092\u5bfe\u8c61\u306b\u3001\u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb12\u9031\uff0b\u30c8\u30e9\u30b9\u30c4\u30ba\u30de\u30d6\u8a081\u5e74\u306e\u5358\u7fa4\u7b2cII\u76f8\u3002\u6700\u7d4210\u5e74\u89e3\u6790\u306710\u5e74iDFS 91.3%\u3001RFI 96.3%\u3001OS 94.3%\u3001\u4e73\u764c\u7279\u7570\u7684\u751f\u5b5898.8%\u3068\u6975\u3081\u3066\u826f\u597d\u3067\u3057\u305f\u3002\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u306f\u8ab2\u984c\u3067\u3059\u304c\u3001**T1b\/c\u3084\u81e8\u5e8a\u7684\u306b\u201c\u4f4e\u301c\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u201d**\u306e\u591a\u304f\u3067\u73fe\u5b9f\u7684\u306a\u7b2c\u4e00\u9078\u629e\u3067\u3059\u3002 T-DM1\u5358\u52641\u5e74\uff08ATEMPT\uff09 ATEMPT\u8a66\u9a13\uff08T-DM1 1\u5e74 vs TH\u30013:1\u7121\u4f5c\u70ba\u5316\uff095\u5e74\u8ffd\u8de1\u3067\u306f\u3001T-DM1\u7fa4\u306e5\u5e74iDFS 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47%\u3067\u540c\u7a0b\u5ea6\u306a\u304c\u3089\u3001T-DM1\u306f\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u30fb\u8131\u6bdb\u304c\u5c11\u306a\u304f\u3001\u4e00\u65b9\u3067\u809d\u9175\u7d20\u4e0a\u6607\u30fb\u8840\u5c0f\u677f\u6e1b\u5c11\u3001\u6cbb\u7642\u4e2d\u6b62\u30fb\u30fb\u30fb<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[28,13],"tags":[],"class_list":["post-649","post","type-post","status-publish","format-standard","hentry","category-her2","category-13"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/649"}],"collection":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/comments?post=649"}],"version-history":[{"count":1,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/649\/revisions"}],"predecessor-version":[{"id":650,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/posts\/649\/revisions\/650"}],"wp:attachment":[{"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/media?parent=649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/categories?post=649"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tokyo-breast-clinic.jp\/seminar\/wp-json\/wp\/v2\/tags?post=649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}